Variations in Reverse Transcriptase and RNase H Domain Mutations in Human Immunodeficiency Virus Type 1 Clinical Isolates Are Associated with Divergent Phenotypic Resistance to Zidovudine

Mutations in the RNase H domain of human immunodeficiency virus type 1 RT have been reported to cause resistance to zidovudine (ZDV) in vitro. However, very limited data on the in vivo relevance of these mutations in patients exist to date. This study was designed to determine the relationship betwe...

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Detalhes bibliográficos
Main Authors: Ntemgwa, Michel, Wainberg, Mark A., Oliveira, Maureen, Moisi, Daniela, Lalonde, Richard, Micheli, Valeria, Brenner, Bluma G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151428/
https://ncbi.nlm.nih.gov/pubmed/17724152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00646-07
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