Variations in Reverse Transcriptase and RNase H Domain Mutations in Human Immunodeficiency Virus Type 1 Clinical Isolates Are Associated with Divergent Phenotypic Resistance to Zidovudine

Mutations in the RNase H domain of human immunodeficiency virus type 1 RT have been reported to cause resistance to zidovudine (ZDV) in vitro. However, very limited data on the in vivo relevance of these mutations in patients exist to date. This study was designed to determine the relationship betwe...

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Bibliografiska uppgifter
Huvudupphovsmän: Ntemgwa, Michel, Wainberg, Mark A., Oliveira, Maureen, Moisi, Daniela, Lalonde, Richard, Micheli, Valeria, Brenner, Bluma G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2007
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151428/
https://ncbi.nlm.nih.gov/pubmed/17724152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00646-07
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