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The tandem C2 domains of synaptotagmin contain redundant Ca(2)+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis

Real-time voltammetry measurements from cracked PC12 cells were used to analyze the role of synaptotagmin–SNARE interactions during Ca(2)+-triggered exocytosis. The isolated C2A domain of synaptotagmin I neither binds SNAREs nor inhibits norepinephrine secretion. In contrast, two C2 domains in tande...

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Detalhes bibliográficos
Main Authors: Earles, Cynthia A., Bai, Jihong, Wang, Ping, Chapman, Edwin R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150817/
https://ncbi.nlm.nih.gov/pubmed/11551981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200105020
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