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The tandem C2 domains of synaptotagmin contain redundant Ca(2)+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis
Real-time voltammetry measurements from cracked PC12 cells were used to analyze the role of synaptotagmin–SNARE interactions during Ca(2)+-triggered exocytosis. The isolated C2A domain of synaptotagmin I neither binds SNAREs nor inhibits norepinephrine secretion. In contrast, two C2 domains in tande...
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| Päätekijät: | , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Rockefeller University Press
2001
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2150817/ https://ncbi.nlm.nih.gov/pubmed/11551981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200105020 |
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