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Synaptotagmin–Ca(2+) triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation

Synaptotagmin I (Syt I), the putative Ca(2+) sensor in regulated exocytosis, has two Ca(2+)-binding modules, the C2A and C2B domains, and a number of putative effectors to which Syt I binds in a Ca(2+)-dependent fashion. The role of Ca(2+) binding to these domains remains unclear, as efforts to addr...

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Detalhes bibliográficos
Main Authors: Wang, Chih-Tien, Bai, Jihong, Chang, Payne Y, Chapman, Edwin R, Jackson, Meyer B
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464313/
https://ncbi.nlm.nih.gov/pubmed/16293646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.097378
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