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C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I

Synaptotagmin (syt) I, an integral membrane protein localized to secretory vesicles, is a putative Ca(2+) sensor for exocytosis. Its N terminus spans the membrane once, and its cytoplasmic domain contains two conserved C2 domains, designated C2A and C2B. The isolated C2A domain penetrates membranes...

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Bibliografiska uppgifter
Huvudupphovsmän: Bai, Jihong, Wang, Ping, Chapman, Edwin R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2002
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC122248/
https://ncbi.nlm.nih.gov/pubmed/11805296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032541099
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