A biochemical approach to identifying microRNA targets

Identifying the downstream targets of microRNAs (miRNAs) is essential to understanding cellular regulatory networks. We devised a direct biochemical method for miRNA target discovery that combined RNA-induced silencing complex (RISC) purification with microarray analysis of bound mRNAs. Because targ...

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Detalhes bibliográficos
Main Authors: Karginov, Fedor V., Conaco, Cecilia, Xuan, Zhenyu, Schmidt, Bryan H., Parker, Joel S., Mandel, Gail, Hannon, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2148283/
https://ncbi.nlm.nih.gov/pubmed/18042700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709971104
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