Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.

The crystallographic structures of the ternary complexes of human alpha-thrombin with hirugen (a sulfated hirudin fragment) and the small-molecule active site thrombin inhibitors BMS-186282 and BMS-189090 have been determined at 2.6 and 2.8 A. In both cases, the inhibitors, which adopt very similar...

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Autors principals: Malley, M. F., Tabernero, L., Chang, C. Y., Ohringer, S. L., Roberts, D. G., Das, J., Sack, J. S.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143347/
https://ncbi.nlm.nih.gov/pubmed/8745399
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