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Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.

The crystal structures of two new thrombin inhibitors, P498 and P500, complexed with human alpha-thrombin have been determined at 2.0 A resolution and refined to crystallographic R-factors of 0.170 and 0.169, respectively. These compounds, with picomolar binding constants, belong to a family of pote...

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Detaylı Bibliyografya
Asıl Yazarlar: Féthière, J., Tsuda, Y., Coulombe, R., Konishi, Y., Cygler, M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 1996
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143430/
https://ncbi.nlm.nih.gov/pubmed/8762149
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