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Redox regulation of PI 3-kinase signalling via inactivation of PTEN
The tumour suppressor PTEN is a PtdIns(3,4,5)P(3) phosphatase that regulates many cellular processes through direct antagonism of PI 3-kinase signalling. Here we show that oxidative stress activates PI 3-kinase-dependent signalling via the inactivation of PTEN. We use two assay systems to show that...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC213768/ https://ncbi.nlm.nih.gov/pubmed/14532122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg513 |
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