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PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN

Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss of parkin RBR E3 ubiquitin protein ligase (PRKN, best known as PARK2)—which is...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Gupta, Amit, Anjomani-Virmouni, Sara, Koundouros, Nikos, Poulogiannis, George
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706935/
https://ncbi.nlm.nih.gov/pubmed/29209642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1329692
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