PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all human cancers, and its depletion results in enhanced phosphatidylinositol 3-ki...

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Udgivet i:Mol Cell
Main Authors: Gupta, Amit, Anjomani-Virmouni, Sara, Koundouros, Nikos, Dimitriadi, Maria, Choo-Wing, Rayman, Valle, Adamo, Zheng, Yuxiang, Chiu, Yu-Hsin, Agnihotri, Sameer, Zadeh, Gelareh, Asara, John M., Anastasiou, Dimitrios, Arends, Mark J., Cantley, Lewis C., Poulogiannis, George
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5426642/
https://ncbi.nlm.nih.gov/pubmed/28306514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.02.019
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