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Senescence controls prostatic neoplasia driven by Pten loss
We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a...
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| Publicado no: | Mol Cell Oncol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370383/ https://ncbi.nlm.nih.gov/pubmed/30788414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1511205 |
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