PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo

Genetic ablation of the tumor suppressor PTEN in prostatic epithelial cells (PECs) induces cell senescence. However, unlike oncogene-induced senescence, no hyperproliferation phase and no signs of DNA damage response (DDR) were observed in PTEN-deficient PECs; PTEN loss-induced senescence (PICS) was...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Parisotto, Maxime, Grelet, Elise, El Bizri, Rana, Dai, Yongyuan, Terzic, Julie, Eckert, Doriane, Gargowitsch, Laetitia, Bornert, Jean-Marc, Metzger, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987915/
https://ncbi.nlm.nih.gov/pubmed/29743291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171207
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