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Effects of DNA gyrase inhibitors in Escherichia coli topoisomerase I mutants.

Relaxation of titratable supercoils in bacterial nucleoids was measured following treatment of topA mutants with coumermycin or oxolinic acid, inhibitors of DNA gyrase. Relaxation occurred after treatment of the mutants with either inhibitor. We detected no significant difference in relaxation betwe...

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Autors principals: Pruss, G J, Franco, R J, Chevalier, S G, Manes, S H, Drlica, K
Format: Artigo
Idioma:Inglês
Publicat: 1986
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC213448/
https://ncbi.nlm.nih.gov/pubmed/3019999
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