Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Tetraploidy constitutes an adaptation to stress and an intermediate step between euploidy and aneuploidy in oncogenesis. Tetraploid cells are particularly resistant against genotoxic stress including radiotherapy and chemotherapy. Here, we designed a strategy to preferentially kill tetraploid tumor...

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Main Authors: Vitale, Ilio, Galluzzi, Lorenzo, Vivet, Sonia, Nanty, Lisa, Dessen, Philippe, Senovilla, Laura, Olaussen, Ken A., Lazar, Vladimir, Prudhomme, Michelle, Golsteyn, Roy M., Castedo, Maria, Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2131784/
https://ncbi.nlm.nih.gov/pubmed/18159231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001337
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