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Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway
Tetraploidy constitutes an adaptation to stress and an intermediate step between euploidy and aneuploidy in oncogenesis. Tetraploid cells are particularly resistant against genotoxic stress including radiotherapy and chemotherapy. Here, we designed a strategy to preferentially kill tetraploid tumor...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2007
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2131784/ https://ncbi.nlm.nih.gov/pubmed/18159231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001337 |
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