Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Tetraploidy constitutes an adaptation to stress and an intermediate step between euploidy and aneuploidy in oncogenesis. Tetraploid cells are particularly resistant against genotoxic stress including radiotherapy and chemotherapy. Here, we designed a strategy to preferentially kill tetraploid tumor...

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Hlavní autoři: Vitale, Ilio, Galluzzi, Lorenzo, Vivet, Sonia, Nanty, Lisa, Dessen, Philippe, Senovilla, Laura, Olaussen, Ken A., Lazar, Vladimir, Prudhomme, Michelle, Golsteyn, Roy M., Castedo, Maria, Kroemer, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2131784/
https://ncbi.nlm.nih.gov/pubmed/18159231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001337
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