Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the survival but also for multipolar asymmetric divisions of tetraploid cells, which lead to the generation of aneuploid cells with...

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Detalhes bibliográficos
Main Authors: Vitale, Ilio, Senovilla, Laura, Jemaà, Mohamed, Michaud, Mickaël, Galluzzi, Lorenzo, Kepp, Oliver, Nanty, Lisa, Criollo, Alfredo, Rello-Varona, Santiago, Manic, Gwenola, Métivier, Didier, Vivet, Sonia, Tajeddine, Nicolas, Joza, Nicholas, Valent, Alexander, Castedo, Maria, Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857458/
https://ncbi.nlm.nih.gov/pubmed/20186124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.11
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