Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the survival but also for multipolar asymmetric divisions of tetraploid cells, which lead to the generation of aneuploid cells with...

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Main Authors: Vitale, Ilio, Senovilla, Laura, Jemaà, Mohamed, Michaud, Mickaël, Galluzzi, Lorenzo, Kepp, Oliver, Nanty, Lisa, Criollo, Alfredo, Rello-Varona, Santiago, Manic, Gwenola, Métivier, Didier, Vivet, Sonia, Tajeddine, Nicolas, Joza, Nicholas, Valent, Alexander, Castedo, Maria, Kroemer, Guido
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857458/
https://ncbi.nlm.nih.gov/pubmed/20186124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.11
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