Immunosurveillance against tetraploidization-induced colon tumorigenesis

Circumstantial evidence suggests that colon carcinogenesis can ensue the transient tetraploidization of (pre-)malignant cells. In line with this notion, the tumor suppressors APC and TP53, both of which are frequently inactivated in colon cancer, inhibit tetraploidization in vitro and in vivo. Here,...

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Main Authors: Boilève, Alice, Senovilla, Laura, Vitale, Ilio, Lissa, Delphine, Martins, Isabelle, Métivier, Didier, van den Brink, Stieneke, Clevers, Hans, Galluzzi, Lorenzo, Castedo, Maria, Kroemer, Guido
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587448/
https://ncbi.nlm.nih.gov/pubmed/23324343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23369
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