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Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link,

Proteins that discriminate between cisplatin–DNA adducts and oxaliplatin–DNA adducts are thought to be responsible for the differences in tumor range, toxicity, and mutagenicity of these two important chemotherapeutic agents. However, the structural basis for differential protein recognition of thes...

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Detalhes bibliográficos
Main Authors: Wu, Yibing, Bhattacharyya, Debadeep, King, Candice L., Baskerville-Abraham, Irene, Huh, Sung-Ho, Boysen, Gunnar, Swenberg, James A., Temple, Brenda, Campbell, Sharon L., Chaney, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129171/
https://ncbi.nlm.nih.gov/pubmed/17497831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi062291f
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