Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links

The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on DNA, which in turn influence the binding of da...

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Hauptverfasser: Bhattacharyya, Debadeep, Ramachandran, Srinivas, Sharma, Shantanu, Pathmasiri, Wimal, King, Candice L., Baskerville-Abraham, Irene, Boysen, Gunnar, Swenberg, James A., Campbell, Sharon L., Dokholyan, Nikolay V., Chaney, Stephen G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154474/
https://ncbi.nlm.nih.gov/pubmed/21853154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023582
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