A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1α (HIF-1α) does not impair Pro-564 hydroxylation

BACKGROUND: The hypoxia-inducible factor (HIF) transcription complex, which is activated by low oxygen tension, controls a diverse range of cellular processes including angiogenesis and erythropoiesis. Under normoxic conditions, the α subunit of HIF is rapidly degraded in a manner dependent on hydro...

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Main Authors: Percy, Melanie J, Mooney, Sharon M, McMullin, Mary Frances, Flores, Adrian, Lappin, Terence RJ, Lee, Frank S
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2003
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC212228/
https://ncbi.nlm.nih.gov/pubmed/14521712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-2-31
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