c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth

Cancer cells are able to overproduce lactic acid aerobically, whereas normal cells undergo anaerobic glycolysis only when deprived of oxygen. Tumor aerobic glycolysis was recognized about seven decades ago; however, its molecular basis has remained elusive. The lactate dehydrogenase-A gene (LDH-A),...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shim, Hyunsuk, Dolde, Christine, Lewis, Brian C., Wu, Chyi-Sun, Dang, Gerard, Jungmann, Richard A., Dalla-Favera, Riccardo, Dang, Chi V.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21214/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6658
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