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E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

The helix-loop-helix protein, E47, is essential for both B- and T-lineage development. Here we demonstrate that in vitro E47 and Notch signaling act in concert to promote T cell development from fetal hematopoieitic progenitors and to restrain development into the natural killer and myeloid cell lin...

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Main Authors: Ikawa, Tomokatsu, Kawamoto, Hiroshi, Goldrath, Ananda W., Murre, Cornelis
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2121213/
https://ncbi.nlm.nih.gov/pubmed/16682500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060268
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