Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells

Notch1 signaling is required for T cell development. We have previously demonstrated that expression of a dominant active Notch1 (ICN1) transgene in hematopoietic stem cells (HSCs) leads to thymic-independent development of CD4(+)CD8(+) double-positive (DP) T cells in the bone marrow (BM). To unders...

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Autores principales: Allman, David, Karnell, Fredrick G., Punt, Jennifer A., Bakkour, Sonia, Xu, Lanwei, Myung, Peggy, Koretzky, Gary A., Pui, John C., Aster, Jon C., Pear, Warren S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2001
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193437/
https://ncbi.nlm.nih.gov/pubmed/11435476
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