FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

γ-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for tumors dependent on deregulated NOTCH activity. To clarify the basis for GSI resistance in T cell acute lymphoblastic leukemia (T-ALL), we studied T-ALL cell lines with co...

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Главные авторы: O'Neil, Jennifer, Grim, Jonathan, Strack, Peter, Rao, Sudhir, Tibbitts, Deanne, Winter, Christopher, Hardwick, James, Welcker, Markus, Meijerink, Jules P., Pieters, Rob, Draetta, Giulio, Sears, Rosalie, Clurman, Bruce E., Look, A. Thomas
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2007
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118656/
https://ncbi.nlm.nih.gov/pubmed/17646409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070876
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