FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors

γ-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for tumors dependent on deregulated NOTCH activity. To clarify the basis for GSI resistance in T cell acute lymphoblastic leukemia (T-ALL), we studied T-ALL cell lines with co...

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Main Authors: O'Neil, Jennifer, Grim, Jonathan, Strack, Peter, Rao, Sudhir, Tibbitts, Deanne, Winter, Christopher, Hardwick, James, Welcker, Markus, Meijerink, Jules P., Pieters, Rob, Draetta, Giulio, Sears, Rosalie, Clurman, Bruce E., Look, A. Thomas
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2007
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118656/
https://ncbi.nlm.nih.gov/pubmed/17646409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070876
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