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DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model
Tumor suppressor p53-dependent apoptosis is critical in suppressing tumorigenesis. Previously, we reported that DNA double-strand breaks (DSBs) at the V(D)J recombination loci induced genomic instability in the developing lymphocytes of nonhomologous end-joining (NHEJ)–deficient, p53-deficient mice,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118600/ https://ncbi.nlm.nih.gov/pubmed/17535972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062453 |
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