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DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model

Tumor suppressor p53-dependent apoptosis is critical in suppressing tumorigenesis. Previously, we reported that DNA double-strand breaks (DSBs) at the V(D)J recombination loci induced genomic instability in the developing lymphocytes of nonhomologous end-joining (NHEJ)–deficient, p53-deficient mice,...

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Main Authors: Van Nguyen, Thang, Puebla-Osorio, Nahum, Pang, Hui, Dujka, Melanie E., Zhu, Chengming
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118600/
https://ncbi.nlm.nih.gov/pubmed/17535972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062453
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