Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence

Genotoxic stress triggers the p53 tumor suppressor network to activate cellular responses that lead to cell cycle arrest, DNA repair, apoptosis or senescence. This network functions mainly through transactivation of different downstream targets, including cell cycle inhibitor p21, which is required...

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Главные авторы: Tavana, Omid, Benjamin, Cara L, Puebla-Osorio, Nahum, Sang, Mei, Ullrich, Stephen E, Ananthaswamy, Honnavara N, Zhu, Chengming
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2010
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Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041166/
https://ncbi.nlm.nih.gov/pubmed/20703098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.16.12688
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