A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

Complement is an important component of the innate and adaptive immune response, yet complement split products generated through activation of each of the three complement pathways (classical, alternative, and lectin) can cause inflammation and tissue destruction. Previous studies have shown that co...

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Main Authors: Katschke, Kenneth J., Helmy, Karim Y., Steffek, Micah, Xi, Hongkang, Yin, JianPing, Lee, Wyne P., Gribling, Peter, Barck, Kai H., Carano, Richard A.D., Taylor, Robin E., Rangell, Linda, Diehl, Lauri, Hass, Philip E., Wiesmann, Christian, van Lookeren Campagne, Menno
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Brief Definitive Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118595/
https://ncbi.nlm.nih.gov/pubmed/17548523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070432
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