Importance of group X–secreted phospholipase A(2) in allergen-induced airway inflammation and remodeling in a mouse asthma model

Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A(2)s (PLA(2)s), most notably cytosolic PLA(2)-α. 10...

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Main Authors: Henderson, William R., Chi, Emil Y., Bollinger, James G., Tien, Ying-tzang, Ye, Xin, Castelli, Luca, Rubtsov, Yuri P., Singer, Alan G., Chiang, Gertrude K.S., Nevalainen, Timo, Rudensky, Alexander Y., Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118555/
https://ncbi.nlm.nih.gov/pubmed/17403936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070029
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