Blockade of Human Group X Secreted Phospholipase A(2) (GX-sPLA(2))-induced Airway Inflammation and Hyperresponsiveness in a Mouse Asthma Model by a Selective GX-sPLA(2) Inhibitor

Group X (GX) phospholipase A(2), a member of a large group of secreted phospholipases A(2) (sPLA(2)s), has recently been demonstrated to play an important in vivo role in the release of arachidonic acid and subsequent formation of eicosanoids. In a Th2 cytokine-driven mouse asthma model, deficiency...

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Detalhes bibliográficos
Main Authors: Henderson, William R., Oslund, Rob C., Bollinger, James G., Ye, Xin, Tien, Ying-tzang, Xue, Jun, Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151050/
https://ncbi.nlm.nih.gov/pubmed/21652694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235812
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