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Blockade of Human Group X Secreted Phospholipase A(2) (GX-sPLA(2))-induced Airway Inflammation and Hyperresponsiveness in a Mouse Asthma Model by a Selective GX-sPLA(2) Inhibitor
Group X (GX) phospholipase A(2), a member of a large group of secreted phospholipases A(2) (sPLA(2)s), has recently been demonstrated to play an important in vivo role in the release of arachidonic acid and subsequent formation of eicosanoids. In a Th2 cytokine-driven mouse asthma model, deficiency...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3151050/ https://ncbi.nlm.nih.gov/pubmed/21652694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235812 |
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