Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1

Prostaglandin E(2) (PGE(2)) exerts its actions via four subtypes of the PGE receptor, EP1–4. We show that mice deficient in EP1 exhibited significantly attenuated Th1 response in contact hypersensitivity induced by dinitrofluorobenzene (DNFB). This phenotype was recapitulated in wild-type mice by ad...

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Autors principals: Nagamachi, Miyako, Sakata, Daiji, Kabashima, Kenji, Furuyashiki, Tomoyuki, Murata, Takahiko, Segi-Nishida, Eri, Soontrapa, Kitipong, Matsuoka, Toshiyuki, Miyachi, Yoshiki, Narumiya, Shuh
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118516/
https://ncbi.nlm.nih.gov/pubmed/17967902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070773
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