Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus

DNA vaccines offer promising strategies for immunization against infections. However, their clinical use requires improvements in immunogenicity. We explored the efficacy of Toll-like receptor (TLR) ligands (TLR-Ls) on augmenting the immunogenicity of a DNA prime–modified vaccinia virus Ankara (MVA)...

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Detalhes bibliográficos
Main Authors: Kwissa, Marcin, Amara, Rama R., Robinson, Harriet L., Moss, Bernard, Alkan, Sefik, Jabbar, Abdul, Villinger, Francois, Pulendran, Bali
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118478/
https://ncbi.nlm.nih.gov/pubmed/17954572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071211
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