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Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

TLR ligands (TLR-Ls) represent novel vaccine adjuvants, but their immunologic effects in humans remain poorly defined in vivo. In the present study, we analyzed the innate responses stimulated by different TLR-Ls in rhesus macaques. MPL (TLR4-L), R-848 (TLR7/8-L), or cytosine-phosphate-guanine oligo...

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Detalhes bibliográficos
Main Authors: Kwissa, Marcin, Nakaya, Helder I., Oluoch, Herold, Pulendran, Bali
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311246/
https://ncbi.nlm.nih.gov/pubmed/22246032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-388579
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