Autocrine/paracrine TGFβ1 is required for the development of epidermal Langerhans cells

Langerhans cells (LCs) are bone marrow (BM)–derived epidermal dendritic cells (DCs) that develop from precursors found in the dermis. Epidermal LCs are absent in transforming growth factor (TGF) β1-deficient mice. It is not clear whether TGFβ1 acts directly on LC precursors to promote maturation or...

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Detalhes bibliográficos
Main Authors: Kaplan, Daniel H., Li, Ming O., Jenison, Matthew C., Shlomchik, Warren D., Flavell, Richard A., Shlomchik, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118472/
https://ncbi.nlm.nih.gov/pubmed/17938236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071401
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