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Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration

Langerhans cells (LCs) are skin-resident dendritic cells (DC) located in the epidermis that migrate to skin-draining lymph nodes during the steady state and in response to inflammatory stimuli. TGF-β1 is a critical immune regulator that is highly expressed by LCs. The ability to test the functional...

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Autors principals: Bobr, Aleh, Igyarto, Botond Z., Haley, Krystal M., Li, Ming O., Flavell, Richard A., Kaplan, Daniel H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387113/
https://ncbi.nlm.nih.gov/pubmed/22689996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119178109
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