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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

B cells responding to T-dependent antigen either differentiate rapidly into extrafollicular plasma cells or enter germinal centers and undergo somatic hypermutation and affinity maturation. However, the physiological cues that direct B cell differentiation down one pathway versus the other are unkno...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Paus, Didrik, Phan, Tri Giang, Chan, Tyani D., Gardam, Sandra, Basten, Antony, Brink, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118299/
https://ncbi.nlm.nih.gov/pubmed/16606676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20060087
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