Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kräutler, Nike J., Suan, Dan, Butt, Danyal, Bourne, Katherine, Hermes, Jana R., Chan, Tyani D., Sundling, Christopher, Kaplan, Warren, Schofield, Peter, Jackson, Jennifer, Basten, Antony, Christ, Daniel, Brink, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413338/
https://ncbi.nlm.nih.gov/pubmed/28363897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161533
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