In vivo analysis of the role of aberrant histone deacetylase recruitment and RARα blockade in the pathogenesis of acute promyelocytic leukemia

The promyelocytic leukemia–retinoic acid receptor α (PML-RARα) protein of acute promyelocytic leukemia (APL) is oncogenic in vivo. It has been hypothesized that the ability of PML-RARα to inhibit RARα function through PML-dependent aberrant recruitment of histone deacetylases (HDACs) and chromatin r...

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Detalhes bibliográficos
Main Authors: Matsushita, Hiromichi, Scaglioni, Pier Paolo, Bhaumik, Mantu, Rego, Eduardo M., Cai, Lu Fan, Majid, Samia M., Miyachi, Hayato, Kakizuka, Akira, Miller, Wilson H., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118271/
https://ncbi.nlm.nih.gov/pubmed/16549595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050616
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