Treatment with 5-Azacytidine Accelerates Acute Promyelocytic Leukemia Leukemogenesis in a Transgenic Mouse Model

A key oncogenic force in acute promyelocytic leukemia (APL) is the ability of the promyelocytic leukemia–retinoic acid receptor α (PML-RARA) oncoprotein to recruit transcriptional repressors and DNA methyltransferases at retinoic acid–responsive elements. Pharmacological doses of retinoic acid relie...

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Detalhes bibliográficos
Main Authors: Scaglioni, Pier Paolo, Cai, Lu Fan, Majid, Samia M., Yung, Thomas M., Socci, Nicholas D., Kogan, Scott C., Kopelovich, Levy, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2011
Assuntos:
Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111249/
https://ncbi.nlm.nih.gov/pubmed/21779489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601911410300
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