Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is associated with chromosomal translocations, invariably involving the retinoic acid receptor α (RARα) gene fused to one of several distinct loci, including the PML or PLZF genes, involved in t(15;17) or t(11;17), respectively. Patients with t(15;17) APL respond w...

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Main Authors: He, Li-Zhen, Tolentino, Thomas, Grayson, Peter, Zhong, Sue, Warrell, Raymond P., Rifkind, Richard A., Marks, Paul A., Richon, Victoria M., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC209432/
https://ncbi.nlm.nih.gov/pubmed/11696577
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