Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease

Though Abl inhibitors are often successful therapies for the initial stages of chronic myelogenous leukemia (CML), refractory cases highlight the need for novel molecular insights. We demonstrate that mice deficient in the enzyme 12/15-lipoxygenase (12/15-LO) develop a myeloproliferative disorder (M...

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Main Authors: Middleton, Melissa Kristine, Zukas, Alicia Marie, Rubinstein, Tanya, Jacob, Michele, Zhu, Peijuan, Zhao, Liang, Blair, Ian, Puré, Ellen
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2006
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118138/
https://ncbi.nlm.nih.gov/pubmed/17043146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061444
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