Knockout of the abetalipoproteinemia gene in mice: Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes

Abetalipoproteinemia, an inherited human disease characterized by a near-complete absence of the apolipoprotein (apo) B-containing lipoproteins in the plasma, is caused by mutations in the gene for microsomal triglyceride transfer protein (MTP). We used gene targeting to knock out the mouse MTP gene...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Raabe, Martin, Flynn, Laura M., Zlot, Constance H., Wong, Jinny S., Véniant, Murielle M., Hamilton, Robert L., Young, Stephen G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21137/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671739/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8686
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