Knockout of the abetalipoproteinemia gene in mice: Reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes

Abetalipoproteinemia, an inherited human disease characterized by a near-complete absence of the apolipoprotein (apo) B-containing lipoproteins in the plasma, is caused by mutations in the gene for microsomal triglyceride transfer protein (MTP). We used gene targeting to knock out the mouse MTP gene...

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Bibliographische Detailangaben
Hauptverfasser: Raabe, Martin, Flynn, Laura M., Zlot, Constance H., Wong, Jinny S., Véniant, Murielle M., Hamilton, Robert L., Young, Stephen G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1998
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC21137/
https://ncbi.nlm.nih.gov/pubmed/9671739
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