Engineering subunit association of multisubunit proteins: A dimeric streptavidin
A dimeric streptavidin has been designed by molecular modeling using effective binding free energy calculations that decompose the binding free energy into electrostatic, desolvation, and side chain entropy loss terms. A histidine-127 → aspartic acid (H127D) mutation was sufficient to introduce elec...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21018/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9177186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.12.6153 |
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