Engineering subunit association of multisubunit proteins: A dimeric streptavidin

A dimeric streptavidin has been designed by molecular modeling using effective binding free energy calculations that decompose the binding free energy into electrostatic, desolvation, and side chain entropy loss terms. A histidine-127 → aspartic acid (H127D) mutation was sufficient to introduce elec...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Sano, Takeshi, Vajda, Sandor, Smith, Cassandra L., Cantor, Charles R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1997
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21018/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9177186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.12.6153
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