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Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.

Biosynthesis of cephalosporin antibiotics involves an expansion of the five-membered thiazolidine ring of penicillin N to the six-membered dihydrothiazine ring of deacetoxycephalosporin C by a deacetoxycephalosporin C synthetase (DAOCS) enzyme activity. Hydroxylation of deacetoxycephalosporin C to f...

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Detalhes bibliográficos
Publicado no:J Bacteriol
Principais autores: Kovacevic, S, Weigel, B J, Tobin, M B, Ingolia, T D, Miller, J R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209661/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2644235/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.171.2.754-760.1989
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