Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1

Using resting cells and extracts of Streptomyces clavuligerus NP1, we have been able to convert penicillin G (benzylpenicillin) to deacetoxycephalosporin G. Conversion was achieved by increasing by 45× the concentration of FeSO(4) (1.8 mM) and doubling the concentration of α-ketoglutarate (1.28 mM)...

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Detalhes bibliográficos
Main Authors: Cho, Hiroshi, Adrio, José L., Luengo, José M., Wolfe, Saul, Ocran, Simeon, Hintermann, Gilberto, Piret, Jacqueline M., Demain, Arnold L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21677/
https://ncbi.nlm.nih.gov/pubmed/9751702
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